PADRE: Pedigree-Aware Distant-Relationship Estimation
نویسندگان
چکیده
منابع مشابه
Risk Estimation and Pedigree Analysis
For geneticists, an assessment of the likelihood of a particular woman developing breast cancer, given her pedigree, is a necessary but not sufficient prerequisite for the provision of advice about her management. While a variety of methods of risk assessment have been proposed over the last ten years, based on data from a variety of sources, geneticists should only feel comfortable using metho...
متن کاملIdentification of Pedigree Relationship from Genome Sharing
Determination of degree of relationship traditionally has been undertaken using genotypic data on individual loci, typically assumed to be independent. With dense marker data as now available, it is possible to identify the regions of the genome shared identical by descent (ibd). This information can be used to determine pedigree relationship (R), e.g., cousins vs. second cousins, and also to d...
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Earlier work with the Parallel Document Retrieval Engine was oriented toward parallel machines such as the AP1000, characterised by many nodes, few disks, small memory per node (by current standards), single-user operation and high communication performance, relative to node computational power. Present generation parallel machines are much more like clusters of workstations (COWs). There are t...
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Dense molecular markers are being used in genetic evaluation for parts of the population. This requires a two-step procedure where pseudo-data (for instance, daughter yield deviations) are computed from full records and pedigree data and later used for genomic evaluation. This results in bias and loss of information. One way to incorporate the genomic information into a full genetic evaluation ...
متن کاملRelationship-aware sequential pattern mining
Relationship-aware sequential pattern mining is the problem of mining frequent patterns in sequences in which the events of a sequence are mutually related by one or more concepts from some respective hierarchical taxonomies, based on the type of the events. Additionally events themselves are also described with a certain number of taxonomical concepts. We present RaSP an algorithm that is able...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2016
ISSN: 0002-9297
DOI: 10.1016/j.ajhg.2016.05.020